1. 2Resident of Veterinary Surgery, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran 2. Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman
The present article was aimed to clarify the role of central adenosine on food intake in neonatal chicks. adenosine is now recognized as a neurotransmitter and a presynaptic modulator of transmitter release in the brain. both adenosine and atp/adp are now recognized to act via p1 and p2 receptors, respectively these receptors are widely expressed in the brain.
In this study, the effect of intracerebroventricular (icv) administration of adenosine and cgs15943 (a general p1 receptor antagonist) on food intake was investigated in neonatal chicks. three hours fasting was applied to chicks prior to injection adenosine. in experiment 1 various doses of adenosine were injected to chicks were eaten with normal diet. in experiment 2 and 3 the birds were received normal diet and were administrated different doses of cgs15943. in experiment 4 and 5 cgs15943 and adenosine were injected to chicks respectively which were fed with high fat diet.
The results of this study showed the both food and fat intake did not alter by icv injection of adenosine but cgs15943 increased both food and fat intake in a very limited dose range.
In this study was demonstrated that inhibition of adenosine receptors (p1) leads to increase both food and fat intake which represents involvement of adenosine receptors (p1) in food intake of neonatal chicks in antagonistic manner.